Dissociation of pressure-rate product from myocardial oxygen consumption in dog.

Rate-pressure product correlates poorly with myocardial oxygen consumption during anaesthesia in coronary patients.

In 26 patients having coronary grafts, haemodynamics, coronary sinus blood flow and the arterio-coronary sinus difference of oxygen content were determined, awake and at four intervals during morphine-oxygen or halothane--oxygen anaesthesia. Rate-pressure product (RPP), triple product (TP) and myocardial oxygen consumption (MVO2) were calculated. The correlation of the two indirect indices to M...

The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris.

In order to evaluate hemodynamic predictors of myocardial oxygen consumption (MVO2), 27 normotensive men with angina pectoris were studied at rest and during a steady state at sympton-tolerated maximal exercise (STME). Myocardial blood flow (MBF) was measured by the nitrous oxide method using gas chromatography. MBF increased by 71% from a resting value of 57.4 +/- 10.2 to 98.3 +/- 15.6 ml/100 ...

Oxygen Consumption in Dog Left Ventricle

In 10 excised, cross-circulated, isovolumically beating dog left ventricles, we examined the effects of bigeminy, including, paired-pulse stimulation, on cardiac oxygen consumption (Vo2) and evaluated whether the Vo2 versus pressure-volume area (PVA) relation obtained from regularly beating hearts in our previous studies could account for the changes in Vo2 during bigeminies with various coupli...

Independence of myocardial oxygen consumption from pressure-volume trajectory during diastole in canine left ventricle.

We have found that myocardial oxygen consumption is linearly correlated with the systolic pressure-volume area in the canine left ventricle. This pressure-volume area is a specific area in the pressure-volume diagram that is circumscribed by the end-systolic pressure-volume relation line, the end-diastolic pressure-volume relation curve, and the systolic segment of the pressure-volume trajector...

Effects of glucagon on myocardial oxygen consumption and coronary blood flow in man and in dog.